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Article

Experimental models of transcription factor-associated maturity-onset diabetes of the young.

Diabetes - 1 Dec 2002

Wang Haiyan, Hagenfeldt-Johansson Kerstin, Otten Luc A, Gauthier Benoit R, Herrera Pedro L, Wollheim Claes B

Abstract excerpt

Six monogenic forms of maturity-onset diabetes of the young (MODY) have been identified to date. Except for MODY2 (glucokinase), all other MODY subtypes have been linked to transcription factors. We have established a MODY3 transgenic model through the beta-cell-targeted expression of dominant-negative HNF-1alpha either constitutively (rat insulin II promoter) or conditionally (Tet-On system). The animals display...

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PMID: 12475772
DOI: 10.2337/diabetes.51.2007.s333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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