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Understanding the contextual functions of C1q and LAIR-1 and their applications

13 May 2022

Abstract excerpt

The importance of the complement component C1q has been highlighted by its involvement in autoimmunity, infection, inflammatory diseases, and tumors. The unique tulip-like structure of C1q has both a collagen-like stalk (C1q tail) and heterotrimeric globular head (gC1q), each with different binding specificities, and the binding of these components to their respective receptors leads to functional complexities in...

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PMID: 35562585
DOI: 10.1038/s12276-022-00774-4

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