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Article

Cytokine gene polymorphisms associating with severe acute graft-versus-host disease in HLA-identical sibling transplants.

Blood - 15 Nov 1998

Middleton P G, Taylor P R, Jackson G, Proctor S J, Dickinson A M

Abstract excerpt

It is now well known that the initial phase of graft-versus-host disease (GVHD) involves cytokine release during preconditioning of the recipient of an allogeneic bone marrow transplant (BMT). Tumor necrosis factor (TNF), in particular, has been implicated in pathological damage and is released pretransplant due to irradiation and cytotoxic preconditioning regimens. Interleukin-10 (IL-10), a natural...

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PMID: 9808588

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TNF

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Cytokine gene polymorphisms associating with severe acute graft-versus-host disease in HLA-identical sibling transplants.PMID 9808588Read ↗

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