Article
IL10 and IL10 receptor gene variation and outcomes after unrelated and related hematopoietic cell transplantation.
Transplantation - 15 Mar 2009
Tseng Li-Hui, Storer Barry, Petersdorf Effie, Lin Ming-Tseh, Chien Jason W, Grogan Bryan M, Malkki Mari, Chen Pei-Jer, Zhao Lue P, Martin Paul J, Hansen John A
Abstract excerpt
BACKGROUND: Results of a previous study with human leukocyte antigen (HLA)-identical siblings showed individual and synergistic associations of single nucleotide polymorphisms in the promoter region of the recipient's IL10 gene and the donor's IL10 receptor beta (IL-10RB) gene with development of grades III-IV acute graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation. METHODS: In...
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