Article
High-producer interleukin-2 genotype increases risk for acute graft-versus-host disease after unrelated donor bone marrow transplantation.
Transplantation - 27 Dec 2003
MacMillan Margaret L, Radloff Gretchen A, Kiffmeyer William R, DeFor Todd E, Weisdorf Daniel J, Davies Stella M
Abstract excerpt
BACKGROUND: Cytokine polymorphisms may modulate immunologic reactivity, including graft-versus-host disease (GVHD). A single nucleotide polymorphism resulting in a thymine-to-guanine transition in the interleukin (IL)-2 gene promoter region occurs at position -330. In vitro studies have shown that the G allele is associated with early and sustained enhancement of IL-2 production, a so-called high-producer...
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