Article
Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation.
The New England journal of medicine - 4 Dec 2003
Lin Ming-Tseh, Storer Barry, Martin Paul J, Tseng Li-Hui, Gooley Ted, Chen Pei-Jer, Hansen John A
Abstract excerpt
BACKGROUND: Polymorphisms in cytokine genes can influence immune responses, inflammation, and tissue injury and may affect the outcome of hematopoietic stem-cell transplantation. METHODS: We analyzed single-nucleotide polymorphisms in the genes for interleukin-1beta, interleukin-1-receptor antagonist, interleukin-6, interleukin-10 (IL10), and tumor necrosis factor alpha in 570 transplant recipients and their...
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