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Article

SARS-CoV-2 Spike Protein Mutation at Cysteine-488 Impairs Its Golgi Localization and Intracellular S1/S2 Processing.

International journal of molecular sciences - 13 Dec 2022

Yamamoto Yuichiro, Inoue Tetsuya, Inoue Miyu, Murae Mana, Fukasawa Masayoshi, Kaneko Mika K, Kato Yukinari, Noguchi Kohji

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein binds to the cellular receptor-angiotensin-converting enzyme-2 (ACE2) as the first step in viral cell entry. SARS-CoV-2 spike protein expression in the ACE2-expressing cell surface induces cell-cell membrane fusion, thus forming syncytia. To exert its fusogenic activity, the spike protein is typically processed at a specific site (the...

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Identifiers

PMID: 36555473
DOI: 10.3390/ijms232415834
PMCID: PMC9779352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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