Article
CCL3 aggravates intestinal damage in NEC by promoting macrophage chemotaxis and M1 macrophage polarization.
Pediatric research - 1 Jul 2023
Yuan Xi, Liu Wei, Li Yue, Chen Kai, Li Hongdong, Tang Hong, Yin Yibing, Song Zhixin, Chen Dapeng
Abstract excerpt
BACKGROUND: NEC is a life-threatening gastrointestinal disease in neonates, the pathogenesis of which remains poorly understood. METHODS: CCL3 levels in intestinal tissue of mice were measured and analyzed. HE staining was used to assess pathological changes in intestinal tissue. FCM was used to detect the proportion and phenotype of macrophages. RNA-seq and RT-PCR were used to evaluate the effect of CCL3 on...
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