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Article

Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities

13 Nov 2020

Abstract excerpt

Abstract Necrotizing enterocolitis (NEC) is a severe, currently untreatable intestinal disease that predominantly affects preterm infants and is driven by poorly characterized inflammatory pathways. Here, human and murine NEC intestines exhibit an unexpected predominance of type 3/TH17 polarization. In murine NEC, pro-inflammatory type 3 NKp46−RORγt+Tbet+innate lymphoid cells (ILC3) are 5-fold increased, whereas...

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PMID: 33188181
DOI: 10.1038/s41467-020-19400-w

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