Article

CCL3 aggravates intestinal tissue damage in NEC by promoting macrophage chemotaxis and M1 macrophage polarization.

2022-01-31

Abstract excerpt

<title>Abstract</title> <p>Necrotizing enterocolitis (NEC) is a life-threatening inflammatory gastrointestinal disease in neonates, the mechanism of which is poorly elucidated. Intestinal mucosal barrier imbalance due to excessive inflammatory response is an important endogenous cause of NEC. Our study elucidates a novel mechanism of NEC development, in which CCL3 regulated the chemotaxis, polarization, and funct...

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Literature Corpus work: b0d5ebd0-8c96-5c63-94fa-8213ac2aff7f
DOI: 10.21203/rs.3.rs-1283126/v1

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