Article

CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization

2024-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Acute myeloid leukemia (AML) is a malignancy of immature myeloid blast cells with stem-like and chemoresistant cells being retained in the bone marrow through CXCL12-CXCR4 signaling. Current CXCR4 inhibitors that mobilize AML cells into the bloodstream have failed to improve patient survival, likely reflecting persistent chemokine receptor localization on target cells. Here we characterize the s...

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Literature Corpus work: 7b3b00ca-7f54-51a6-93c1-5b508d260da1
DOI: 10.1101/2024.08.26.609725

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