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Article

C-X-C motif chemokine 12 influences the development of extramedullary hematopoiesis in the spleens of myelofibrosis patients.

Experimental hematology - 1 Feb 2015

Wang Xiaoli, Cho Sool Yeon, Hu Cing Siang, Chen Daniel, Roboz John, Hoffman Ronald

Abstract excerpt

Myelofibrosis (MF) is characterized by the constitutive mobilization of hematopoietic stem cells (HSC) and hematopoietic progenitor cells (HPC) and the establishment of extramedullary hematopoiesis. The mechanisms underlying this abnormal HSC/HPC trafficking pattern remain poorly understood. We demonstrated that both splenic and peripheral blood (PB) MF CD34(+) cells equally share a defective ability to home to...

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Topics

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Share to Antibodies, Neutralizing
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Microenvironment

Share to Chemokine CXCL12

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Share to Mice, Inbred NOD

Share to Primary Myelofibrosis

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Source

Open in PubMed Open full text

Identifiers

PMID: 25461253
DOI: 10.1016/j.exphem.2014.10.013
PMCID: PMC4324010

Genes

CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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