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CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment

28 Mar 2017

Abstract excerpt

The microenvironment is an important regulator of hematopoietic stem and progenitor cell (HSPC) biology. Recent advances marking fluorescent HSPCs have allowed exquisite visualization of HSPCs in the caudal hematopoietic tissue (CHT) of the developing zebrafish. Here, we show that the chemokine cxcl8 and its receptor, cxcr1, are expressed by zebrafish endothelial cells, and we identify cxcl8/cxcr1 signaling as a...

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PMID: 28351983
DOI: 10.1084/jem.20161616

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