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Article

The effect of sensory deprivation and mutant gene dosage on seizures and sustained attention in a mouse model of absence epilepsy.

Epilepsy & behavior : E&B - 1 Apr 2026

Ortiz Erika, Yang Ryan, Sonesra Alina, Ntamatungiro Axel K, Ruiz Max, Dunbar Corrinne, Chavez Ana, Moscoso Bruno, Park Suhyeorn Jane, Maheshwari Atul

Abstract excerpt

OBJECTIVES: Attention-deficit/hyperactivity disorder (ADHD) is a frequent comorbidity in epilepsy, particularly absence epilepsy, but the mechanistic links between these conditions remain poorly understood. We evaluated attention and seizure susceptibility in a genetically tractable mouse model carrying heterozygous and homozygous mutations in Cacng2, a gene encoding an AMPA receptor-associated membrane protein...

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Identifiers

PMID: 41671783
DOI: 10.1016/j.yebeh.2026.110903
PMCID: PMC13499597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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