Article

Characterization of a gene-trap knockout mouse model of <i>Scn2a</i> encoding voltage-gated sodium channel Nav1.2

2020-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Recent large-scale genomic studies have revealed SCN2A as one of the most frequently mutated gene in patients with neurodevelopmental disorders including autism spectrum disorder and intellectual disability. SCN2A encodes for voltage-gated sodium channel isoform 1.2 (Nav1.2), which is mainly expressed in the central nervous system and responsible for the propagation of neuronal action potentia...

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Literature Corpus work: c00062e6-31ba-50e8-8870-dc9a0cd142b1
DOI: 10.1101/2020.06.23.150367

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