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The RNA content of extracellular vesicles from <i>PRPF31</i> <sup>+/−</sup> hiPSC-RPE show potential as biomarkers of retinal degeneration

2022-04-06

Abstract excerpt

Retinitis pigmentosa (RP), is the most common inherited retinal degeneration (IRD), leading to vision loss via dysfunction and death of photoreceptor cells and retinal pigment epithelium (RPE). Mutations in the pre-mRNA processing factor 31 ( PRPF31 ) gene are associated with autosomal dominant RP, impairing RPE function. While adeno-associated virus (AAV)-mediated gene therapy shows promise for treating IRDs, th...

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Literature Corpus work
867a8bb6-ccdf-5a0c-a320-dd39053e541a
DOI
10.1101/2022.04.05.487197
Open publication

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The RNA content of extracellular vesicles from <i>PRPF31</i> <sup>+/−</sup> hiPSC-RPE show potential as biomarkers of retinal degenerationDOI 10.1101/2022.04.05.487197
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