Article

Extracellular vesicles and their miRNA cargo in retinal health and degeneration: mediators of homeostasis, and vehicles for targeted gene therapy

2020-03-30

Abstract excerpt

1.1. <h4>Purpose</h4> Photoreceptor cell death and inflammation are known to occur progressively in retinal degenerative diseases, however the molecular mechanisms underlying these biological processes are largely unknown. Extracellular vesicles (EV) are essential mediators of cell-to-cell communication with emerging roles in the modulation of immune responses. EVs including exosomes encapsulate and transfer nucl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee50d6f6-73fe-5dae-a1c9-958d738a1fdc
DOI: 10.1101/2020.03.29.014910

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Extracellular vesicles and their miRNA cargo in retinal health and degeneration: mediators of homeostasis, and vehicles for targeted gene therapyDOI 10.1101/2020.03.29.014910Read

Rescuing Photoreceptors in RPE Dysfunction-Driven Retinal Degeneration: The Role of Small Extracellular Vesicles Secreted from Retinal Pigment EpitheliumSemantic proximity Read

Small Extracellular Vesicles And Oxidative Pathophysiological Mechanisms In Retinal Degenerative DiseasesSemantic proximity Read

Extracellular vesicles: an emerging player in retinal homeostasisSemantic proximity Read

Emerging Role of Exosomes in Retinal DiseasesSemantic proximity Read

Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degenerationSemantic proximity Read

Exosomes in Ocular Health: Recent Insights into Pathology, Diagnostic Applications and Therapeutic FunctionsSemantic proximity Read

Biophysical, Molecular and Proteomic profiling of Human Retinal Organoids derived ExosomesSemantic proximity Read

Exosomes in Ocular Health and DiseaseSemantic proximity Read

Dynamics of MicroRNA Secreted via Extracellular Vesicles During the Maturation of Embryonic Stem Cell-Derived Retinal Pigment EpitheliumSemantic proximity Read

Exosome-based crosstalk in glaucoma pathogenesis: a focus on oxidative stress and neuroinflammationSemantic proximity Read

Human retinal organoids release extracellular vesicles that regulate gene expression in target human retinal progenitor cellsSemantic proximity Read

Human Retinal Organoids Release Extracellular Vesicles That Regulate Gene Expression in Target Human Retinal Progenitor CellsSemantic proximity Read