Article
Genomic heterogeneity as a barrier to precision oncology in urothelial cancer.
Cell reports - 20 Dec 2022
Clinton Timothy N, Chen Ziyu, Wise Hannah, Lenis Andrew T, Chavan Shweta, Donoghue Mark T A, Almassi Nima, Chu Carissa E, Dason Shawn, Rao Pavitra, Rodrigues James A, Vasani Naresh B, Ridouani Fourat, Rosenberg Jonathan E, Bajorin Dean F, Teo Min Yuen, Bochner Bernard H, Berger Michael F, Ostrovnaya Irina, Pietzak Eugene J, Iyer Gopa, Gao Sizhi Paul, Hu Wenhuo, Al-Ahmadie Hikmat A, Solit David B
Abstract excerpt
Precision oncology relies on the accurate molecular characterization of individual patients with cancer at the time of treatment initiation. However, tumor molecular profiles are not static, and cancers continually evolve because of ongoing mutagenesis and clonal selection. Here, we performed genomic analyses of primary tumors, metastases, and plasma collected from individual patients to define the concordance of...
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