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Article

Effects of CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy subjects.

Archives of pharmacal research - 1 Feb 2023

Cho Chang-Keun, Byeon Ji-Young, Kang Pureum, Park Hye-Jung, Ko Eunvin, Mu Chou Yen, Jang Choon-Gon, Lee Seok-Yong, Lee Yun Jeong

Abstract excerpt

Tolperisone hydrochloride is a centrally-acting muscle relaxant used for relieving spasticities of neurological origin and muscle spasms associated with painful locomotor diseases. It is metabolized to the inactive metabolite mainly by CYP2D6 and, to a lesser extent, by CYP2C19 and CYP1A2. In our previous study, the pharmacokinetics of tolperisone was significantly affected by the genetic polymorphism of CYP2D6,...

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Share to Cytochrome P-450 CYP2C19
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36564599
DOI: 10.1007/s12272-022-01423-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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