Article
Bcl6 drives stem-like memory macrophages differentiation to foster tumor progression.
Cellular and molecular life sciences : CMLS - 21 Dec 2022
Zhang Weiwei, Han Qin, Ding Yina, Zhou Huihui, Chen Zhipeng, Wang Jingjing, Xiang Jiaxin, Song Zhengbo, Abbas Muhammad, Shi Liyun
Abstract excerpt
Cancer development is a long-lasting process during which macrophages play a pivotal role. However, how macrophages maintain their cellular identity, persistence, expanding and pro-tumor property during malignant progression remains elusive. Inspired by the recent report of the activation of stem cell-like self-renewal mechanism in mature macrophages, we postulate that intra-tumoral macrophages might be trained...
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