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Article

Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells.

Developmental cell - 11 Mar 2026

Wu Jun, Li Gen, Zhou Jiawen, Sun Xuan, Wang Haoyu, Gong Haipeng, Jiang Peng

Abstract excerpt

Tumor-infiltrating lymphocytes are usually dysfunctional but demonstrate stem cell-like behavior through unclear mechanisms. Here, we report that administration of vitamin B6 or its active form, pyridoxal phosphate (PLP), endows mouse and human CD8+ T cells with improved persistence, stemness-like phenotypes, and tumor clearance capabilities. Lowering PLP by pyridoxal kinase (PDXK) heterozygosity results in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41314217
DOI: 10.1016/j.devcel.2025.10.017

Genes

BACH2
PDXK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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