Article
Combining genome-wide association studies highlight novel loci involved in human facial variation.
Nature communications - 20 Dec 2022
Xiong Ziyi, Gao Xingjian, Chen Yan, Feng Zhanying, Pan Siyu, Lu Haojie, Uitterlinden Andre G, Nijsten Tamar, Ikram Arfan, Rivadeneira Fernando, Ghanbari Mohsen, Wang Yong, Kayser Manfred, Liu Fan
Abstract excerpt
Standard genome-wide association studies (GWASs) rely on analyzing a single trait at a time. However, many human phenotypes are complex and composed by multiple correlated traits. Here we introduce C-GWAS, a method for combining GWAS summary statistics of multiple potentially correlated traits. Extensive computer simulations demonstrated increased statistical power of C-GWAS compared to the minimal p-values of...
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