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Article

Mapping genes for human face shape: Exploration of univariate phenotyping strategies.

PLoS computational biology - 1 Dec 2024

Yuan Meng, Goovaerts Seppe, Vanneste Michiel, Matthews Harold, Hoskens Hanne, Richmond Stephen, Klein Ophir D, Spritz Richard A, Hallgrimsson Benedikt, Walsh Susan, Shriver Mark D, Shaffer John R, Weinberg Seth M, Peeters Hilde, Claes Peter

Abstract excerpt

Human facial shape, while strongly heritable, involves both genetic and structural complexity, necessitating precise phenotyping for accurate assessment. Common phenotyping strategies include simplifying 3D facial features into univariate traits such as anthropometric measurements (e.g., inter-landmark distances), unsupervised dimensionality reductions (e.g., principal component analysis (PCA) and auto-encoder...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39621772
DOI: 10.1371/journal.pcbi.1012617
PMCID: PMC11661606

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