Article
Genome-wide mapping of global-to-local genetic effects on human facial shape.
Nature genetics - 1 Mar 2018
Claes Peter, Roosenboom Jasmien, White Julie D, Swigut Tomek, Sero Dzemila, Li Jiarui, Lee Myoung Keun, Zaidi Arslan, Mattern Brooke C, Liebowitz Corey, Pearson Laurel, González Tomás, Leslie Elizabeth J, Carlson Jenna C, Orlova Ekaterina, Suetens Paul, Vandermeulen Dirk, Feingold Eleanor, Marazita Mary L, Shaffer John R, Wysocka Joanna, Shriver Mark D, Weinberg Seth M
Abstract excerpt
Genome-wide association scans of complex multipartite traits like the human face typically use preselected phenotypic measures. Here we report a data-driven approach to phenotyping facial shape at multiple levels of organization, allowing for an open-ended description of facial variation while preserving statistical power. In a sample of 2,329 persons of European ancestry, we identified 38 loci, 15 of which...
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