Article
Optimized phenotyping of complex morphological traits: enhancing discovery of common and rare genetic variants.
Briefings in bioinformatics - 4 Mar 2025
Yuan Meng, Goovaerts Seppe, Lee Myoung K, Devine Jay, Richmond Stephen, Walsh Susan, Shriver Mark D, Shaffer John R, Marazita Mary L, Peeters Hilde, Weinberg Seth M, Claes Peter
Abstract excerpt
Genotype-phenotype (G-P) analyses for complex morphological traits typically utilize simple, predetermined anatomical measures or features derived via unsupervised dimension reduction techniques (e.g. principal component analysis (PCA) or eigen-shapes). Despite the popularity of these approaches, they do not necessarily reveal axes of phenotypic variation that are genetically relevant. Therefore, we introduce a...
Read the complete abstract on PubMedTopics
- Humans
- Genome-Wide Association Study
- Phenotype
- Genetic Variation
- Algorithms
- Polymorphism, Single Nucleotide