Article
Insights into the genetic architecture of the human face.
Nature genetics - 1 Jan 2021
White Julie D, Indencleef Karlijne, Naqvi Sahin, Eller Ryan J, Hoskens Hanne, Roosenboom Jasmien, Lee Myoung Keun, Li Jiarui, Mohammed Jaaved, Richmond Stephen, Quillen Ellen E, Norton Heather L, Feingold Eleanor, Swigut Tomek, Marazita Mary L, Peeters Hilde, Hens Greet, Shaffer John R, Wysocka Joanna, Walsh Susan, Weinberg Seth M, Shriver Mark D, Claes Peter
Abstract excerpt
The human face is complex and multipartite, and characterization of its genetic architecture remains challenging. Using a multivariate genome-wide association study meta-analysis of 8,246 European individuals, we identified 203 genome-wide-significant signals (120 also study-wide significant) associated with normal-range facial variation. Follow-up analyses indicate that the regions surrounding these signals are...
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