Article
Novel genetic loci affecting facial shape variation in humans.
eLife - 26 Nov 2019
Xiong Ziyi, Dankova Gabriela, Howe Laurence J, Lee Myoung Keun, Hysi Pirro G, de Jong Markus A, Zhu Gu, Adhikari Kaustubh, Li Dan, Li Yi, Pan Bo, Feingold Eleanor, Marazita Mary L, Shaffer John R, McAloney Kerrie, Xu Shu-Hua, Jin Li, Wang Sijia, de Vrij Femke Ms, Lendemeijer Bas, Richmond Stephen, Zhurov Alexei, Lewis Sarah, Sharp Gemma C, Paternoster Lavinia, Thompson Holly, Gonzalez-Jose Rolando, Bortolini Maria Catira, Canizales-Quinteros Samuel, Gallo Carla, Poletti Giovanni, Bedoya Gabriel, Rothhammer Francisco, Uitterlinden André G, Ikram M Arfan, Wolvius Eppo, Kushner Steven A, Nijsten Tamar Ec, Palstra Robert-Jan Ts, Boehringer Stefan, Medland Sarah E, Tang Kun, Ruiz-Linares Andres, Martin Nicholas G, Spector Timothy D, Stergiakouli Evie, Weinberg Seth M, Liu Fan, Kayser Manfred
Abstract excerpt
The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome-wide association studies on 78 facial shape phenotypes quantified from 3-dimensional facial images of 10,115 Europeans identified 24 genetic loci reaching study-wide suggestive association (p < 5 × 10-8), among which 17...
Topics
- Adolescent
- Adult
- Anatomic Landmarks
- Body Patterning
- Child
- Child, Preschool