Mediation of the Same Epigenetic and Transcriptional Effect by Independent Osteoarthritis Risk-Conferring Alleles on a Shared Target Gene, COLGALT2.

doi:10.1002/art.42427

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Article

Mediation of the Same Epigenetic and Transcriptional Effect by Independent Osteoarthritis Risk-Conferring Alleles on a Shared Target Gene, COLGALT2.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2023

Kehayova Yulia S, Wilkinson J Mark, Rice Sarah J, Loughlin John

Abstract excerpt

OBJECTIVE: Over 100 DNA variants have been associated with osteoarthritis (OA), including rs1046934, located within a linkage disequilibrium block encompassing part of COLGALT2 and TSEN15. The present study was undertaken to determine the target gene(s) and the mechanism of action of the OA locus using human fetal cartilage, cartilage from OA and femoral neck fracture arthroplasty patients, and a chondrocyte cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cartilage, Articular

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Identifiers

PMID: 36538011
DOI: 10.1002/art.42427
PMCID: PMC10952352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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