TGFβ+ small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro-angiogenic phenotype.

doi:10.1002/jev2.12294

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Article

TGFβ+ small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro-angiogenic phenotype.

Journal of extracellular vesicles - 1 Dec 2022

Ludwig Nils, Yerneni Saigopalakrishna S, Azambuja Juliana H, Pietrowska Monika, Widłak Piotr, Hinck Cynthia S, Głuszko Alicja, Szczepański Mirosław J, Kärmer Teresa, Kallinger Isabella, Schulz Daniela, Bauer Richard J, Spanier Gerrit, Spoerl Steffen, Meier Johannes K, Ettl Tobias, Razzo Beatrice M, Reichert Torsten E, Hinck Andrew P, Whiteside Theresa L

Abstract excerpt

Transforming growth factor β (TGFβ) is a major component of tumor-derived small extracellular vesicles (TEX) in cancer patients. Mechanisms utilized by TGFβ+ TEX to promote tumor growth and pro-tumor activities in the tumor microenvironment (TME) are largely unknown. TEX produced by head and neck squamous cell carcinoma (HNSCC) cell lines carried TGFβ and angiogenesis-promoting proteins. TGFβ+ TEX stimulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36537293
DOI: 10.1002/jev2.12294
PMCID: PMC9764108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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