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Article

Influence of tumor cell-derived TGF-β on macrophage phenotype and macrophage-mediated tumor cell invasion.

The international journal of biochemistry & cell biology - 1 Dec 2022

Maldonado Laura Andrea González, Nascimento Camyla Rodrigues, Rodrigues Fernandes Natalie Aparecida, Silva Ana Lídia Pinheiro, D'Silva Nisha J, Rossa Carlos

Abstract excerpt

In oral squamous cell carcinoma (OSCC), macrophages are the most abundant immune cell type in the tumor microenvironment (TME). Macrophage infiltration is inversely proportional to prognosis and disease survival, particularly when these tumor-associated macrophages (TAM) assume an M2-like phenotype. This phenotype is determined by cues from the microenvironment, especially tumor cell-secreted molecules, and is...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 36343916
DOI: 10.1016/j.biocel.2022.106330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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