Article
Regulation of mesenchymal stem cell function by TGFβ-1 on mast cell extracellular vesicles – role of endosomal retention
2017-08-04
Abstract excerpt
Extracellular vesicles (EVs) convey biological messages between cells, either by surface-to-surface interaction, or by shuttling of bioactive molecules to a recipient cell cytoplasm. Here we show that EVs released by human primary mast cells or transformed human mast cells (HMC1), carry TGFβ-1 on their surface. EV-associated TGFβ-1 enhance the migratory activity of human mesenchymal stem cells (MSCs) compared to f...
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Identifiers and source
- Literature Corpus work
- 28ab2195-4b35-5c6e-800a-485d651c93db
- DOI
- 10.1101/172213