Extracellular vesicle–hitchhiking nanoliposomes for cancer-associated fibroblast phenotype modulation impede metastasis progression

Abstract excerpt

Metastasis represents a crucial cancer progression and is promoted by cancer-associated fibroblasts (CAFs). Modulating CAFs in distant metastasis is challenging due to their diverse phenotypes and the lack of effective delivery strategies. Inspired by the tropism of tumor extracellular vesicles (Evs) expressing specific integrins toward fibroblasts, we developed a labeling strategy for both tumors and...

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