Article
Characterizing modifier genes of cardiac fibrosis phenotype in hypertrophic cardiomyopathy.
International journal of cardiology - 1 May 2021
Xu Fuyi, Chen Yuanjian, Tillman Kaitlin A, Cui Yan, Williams Robert W, Bhattacharya Syamal K, Lu Lu, Sun Yao
Abstract excerpt
BACKGROUND: Clinical phenotypes of hypertrophic cardiomyopathy (HCM) vary greatly even among patients with the same gene mutations. This variability is largely regulated by unidentified modifier loci. The purpose of the study is to identify modifier genes for cardiac fibrosis-a major phenotype of HCM-using the BXD family, a murine cohort. METHODS: The relative severity of cardiac fibrosis was estimated by...
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