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Article

Evolutionary perspective of Big tau structure: 4a exon variants of MAPT

2 Dec 2022

Abstract excerpt

The MAPT gene encoding the microtubule-associated protein tau can generate multiple isoforms by alternative splicing giving rise to proteins which are differentially expressed in specific areas of the nervous system and at different developmental stages. Tau plays important roles in modulating microtubule dynamics, axonal transport, synaptic plasticity, and DNA repair, and has also been associated with...

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Identifiers

PMID: 36533137
DOI: 10.3389/fnmol.2022.1019999

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