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The unique properties of Big tau in the visual system

18 May 2024

Abstract excerpt

Tau is a microtubule associated protein that plays important roles in regulating the properties of microtubules and axonal transport, as well as tauopathies associated with toxic aggregates leading to neurodegenerative diseases. It is encoded by the MAPT gene forming multiple isoforms (45-60 kDa) by alternative splicing which are developmentally regulated. The high molecular weight (MW) tau isoform of 105 kDa,...

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PMID: 38761116
DOI: 10.1002/cm.21875

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