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Article

Distribution of big tau isoforms in the human central and peripheral nervous system

2025-09-17

Abstract excerpt

<h4>Objective</h4> Tau is widely studied in the field of neurodegenerative disease research, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and select central nervous system (CNS) regions. We sought to characterize big tau molecular composition, anatomical distribution, and relevance to n...

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Literature Corpus work
75299447-3dd1-5cdb-96a1-8605271dfeb6
DOI
10.1101/2025.09.15.676127
Open publication

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Distribution of big tau isoforms in the human central and peripheral nervous systemDOI 10.1101/2025.09.15.676127
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