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Article

An evolutionary roadmap to the microtubule-associated protein MAP Tau

31 Mar 2016

Abstract excerpt

BACKGROUND: The microtubule associated protein Tau (MAPT) promotes assembly and interaction of microtubules with the cytoskeleton, impinging on axonal transport and synaptic plasticity. Its neuronal expression and intrinsic disorder implicate it in some 30 tauopathies such as Alzheimer's disease and frontotemporal dementia. These pathophysiological studies have yet to be complemented by computational analyses of...

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PMID: 27030133
DOI: 10.1186/s12864-016-2590-9

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