Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Big tau: What, how, where and why

14 Aug 2023

Abstract excerpt

Over the last 50 years the different isoforms of tau proteins (45-60 kDa) have been a focus of research because of their roles in modulating the dynamic properties of microtubules shaping the structure and function of neurons but also becoming a center of attention in the pathology of neurodegeneration associated with tauopathies. Much less attention has been given to Big tau, a unique isoform containing exon 4a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroscience and Neuropharmacology Research
Share to S100 Proteins and Annexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37578198
DOI: 10.1002/cm.21772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Big tau: What, how, where and whyPMID 37578198Read ↗

Big Tau: What We Know, and We Need to KnowSemantic proximity Read ↗

The unique properties of Big tau in the visual systemSemantic proximity Read ↗

The unique properties of Big tau in the visual systemSemantic proximity Read ↗

Tau; One Protein, So Many DiseasesSemantic proximity Read ↗

Roles of tau protein in health and diseaseSemantic proximity Read ↗

Distribution of big tau isoforms in the human central and peripheral nervous systemSemantic proximity Read ↗

Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system.Semantic proximity Read ↗

Tau: More than a microtubule‐binding protein in neuronsSemantic proximity Read ↗

The physiology and pathology of microtubule-associated protein tauSemantic proximity Read ↗

Evolutionary perspective of Big tau structure: 4a exon variants of MAPTSemantic proximity Read ↗

Tau and tauopathies.Semantic proximity Read ↗

The six brain‐specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.