Article
Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders.
Brain research. Molecular brain research - 7 May 1999
Janke C, Beck M, Stahl T, Holzer M, Brauer K, Bigl V, Arendt T
Abstract excerpt
The microtubule-associated protein tau regulates the dynamic stability of the neuronal cytoskeleton by interacting with microtubules. It is encoded by a single gene, but expressed in a variety of isoforms due to differential RNA splicing. Six isoforms can be found in the human central nervous system. These isoforms differ in their ability to promote the assembly of microtubules as well as in their capacity to...
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