Article
Molecular basis of JAK2 H608Y and H608N mutations in the pathology of acute myeloid leukemia.
International journal of biological macromolecules - 28 Feb 2023
Li Feng, Lu Zi-Yi, Xue Yu-Tong, Liu Yang, Cao Jiang, Sun Zeng-Tian, Zhang Qi, Xu Meng-Di, Wang Xiao-Yun, Xu Kai-Lin, Wu Qing-Yun
Abstract excerpt
Risk-stratification of acute myeloid leukemia (AML) based on (cyto)genetic aberrations, including hotspot mutations, deletions and point mutations have evolved substantially in recent years. With the development of next-generation sequence technology, more and more novel mutations in the AML were identified. Thus, to unravel roles and mechanism of novel mutations would improve prognostic and predictive abilities....
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