Article
Effects of the I682F mutation on JAK2's activity, structure and stability.
International journal of biological macromolecules - 1 Aug 2015
Li Feng, Li Wei, Liu Yang, Tong Yu-Xue, Zhou Ping, Wang Lin, Chen Chong, Zeng Ling-Yu, Wu Qing-Yun, Wang Xiao-Yun, Xu Kai-Lin
Abstract excerpt
Janus kinase 2 (JAK2) plays important roles in the regulation of varieties cellular processes including cell migration, proliferation and apoptosis. JAK2 I682F genetic mutation existed in the 4-8% of B-cell acute lymphoblastic leukemia (B-ALL). However, roles of this mutation in the development of B-ALL are still unknown. In order to investigation the mechanism of the JAK2 I682F mutation led to B-ALL, series of...
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