Article
An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells.
Frontiers in immunology - 1 Jan 2018
Lieberman Nicole A P, DeGolier Kole, Haberthur Kristen, Chinn Harrison, Moyes Kara W, Bouchlaka Myriam N, Walker Kirsti L, Capitini Christian M, Crane Courtney A
Abstract excerpt
Recent advances in cellular therapies for patients with cancer, including checkpoint blockade and ex vivo-expanded, tumor-specific T cells, have demonstrated that targeting the immune system is a powerful approach to the elimination of tumor cells. Clinical efforts have also demonstrated limitations, however, including the potential for tumor cell antigenic drift and neoantigen formation, which promote tumor...
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