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Article

Langerhans cell histiocytosis: current advances in molecular pathogenesis.

Frontiers in immunology - 1 Jan 2023

Sconocchia Tommaso, Foßelteder Johannes, Sconocchia Giuseppe, Reinisch Andreas

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a rare and clinically heterogeneous hematological disease characterized by the accumulation of mononuclear phagocytes in various tissues and organs. LCH is often characterized by activating mutations of the mitogen-activated protein kinase (MAPK) pathway with BRAFV600E being the most recurrent mutation. Although this discovery has greatly helped in understanding the disease...

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Identifiers

PMID: 37965340
DOI: 10.3389/fimmu.2023.1275085
PMCID: PMC10642229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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