Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis

25 Jul 2019

Abstract excerpt

Abstract Langerhans cell histiocytosis (LCH) is a rare neoplasm predominantly affecting children. It occupies a hybrid position between cancers and inflammatory diseases, which makes it an attractive model for studying cancer development. To explore the molecular mechanisms underlying the pathophysiology of LCH and its characteristic clinical heterogeneity, we investigated the transcriptomic and epigenomic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and rare skin diseases.
Share to Genital Health and Disease
Share to Histiocytic Disorders and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31345789
DOI: 10.1158/2159-8290.cd-19-0138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell HistiocytosisPMID 31345789Read ↗

Notch-dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathologySemantic proximity Read ↗

Transcriptomic landscape of circulating mononuclear phagocytes in Langerhans cell histiocytosis at the single-cell levelSemantic proximity Read ↗

Recent advances in the understanding of Langerhans cell histiocytosisSemantic proximity Read ↗

Indeterminate DC histiocytosis is distinct from LCH and often associated with other hematopoietic neoplasms.Semantic proximity Read ↗

Unravelling the landscape of skin cancer through single-cell transcriptomicsSemantic proximity Read ↗

Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study.Semantic proximity Read ↗

Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?Semantic proximity Read ↗

Dynamic single-cell regulomes characterize human peripheral blood innate lymphoid cell subpopulationsSemantic proximity Read ↗

Single‑cell multi‑omics advances in lymphoma research (Review)Semantic proximity Read ↗

Langerhans Cell Histiocytosis: A Clinicopathologic Review and Molecular Pathogenetic Update.Semantic proximity Read ↗

Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphomaSemantic proximity Read ↗

Genomic Alterations in Langerhans Cell Histiocytosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.