Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis.

doi:10.1186/s12964-022-00917-0

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Article

Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis.

Cell communication and signaling : CCS - 19 Dec 2022

Gao Xue-Min, Li Jian, Cao Xin-Xin

Abstract excerpt

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid malignancy in the "L-group" histiocytosis. Mitogen-activated protein kinase (MAPK) pathway activating mutations are detectable in nearly all LCH lesions. However, the pathogenic roles of MAPK pathway activation in the development of histiocytosis are still elusive. This review will summarize research concerning the landscape and pathogenic roles of...

Topics

Humans
MAP Kinase Signaling System
Histiocytosis, Langerhans-Cell
Signal Transduction
Mitogen-Activated Protein Kinases
Mutation
Proto-Oncogene Proteins B-raf

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PMID: 36536400
DOI: 10.1186/s12964-022-00917-0
PMCID: PMC9764551

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