Malignant Histiocytosis Comprises a Phenotypic Spectrum That Parallels the Lineage Differentiation of Monocytes, Macrophages, Dendritic Cells, and Langerhans Cells.

doi:10.1016/j.modpat.2023.100268

Article

Malignant Histiocytosis Comprises a Phenotypic Spectrum That Parallels the Lineage Differentiation of Monocytes, Macrophages, Dendritic Cells, and Langerhans Cells.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2023

Ravindran Aishwarya, Dasari Surendra, Ruan Gordon J, Artymiuk Cody J, He Rong, Viswanatha David S, Abeykoon Jithma P, Zanwar Saurabh, Young Jason R, Goyal Gaurav, Go Ronald S, Rech Karen L

Abstract excerpt

Malignant histiocytoses (MHs), or the 'M group' of the Histiocyte Society classification, are characterized by neoplastic histiocytes with large pleomorphic nuclei. MH encompasses the diagnoses of histiocytic sarcoma, interdigitating dendritic cell sarcoma, and Langerhans cell sarcoma. We aimed to define the phenotypic spectrum of MH and examine the genotypic features across this spectrum. Using...

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Malignant Histiocytosis Comprises a Phenotypic Spectrum That Parallels the Lineage Differentiation of Monocytes, Macrophages, Dendritic Cells, and Langerhans Cells.

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