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Article

Histiocyte Society blueprint for Langerhans cell histiocytosis research: from cell-of-origin to a more comprehensive cure.

Haematologica - 1 Nov 2025

Pegoraro Francesco, Kondyli Maria, Prudowsky Zachary D, Van Halteren Astrid G S

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a rare myeloid neoplastic disorder driven by tissue-accumulating histiocytes expressing somatic mutations mostly in genes encoding components of the intracellular mitogen-activated protein kinase (MAPK) pathway. Its clinical presentation is highly variable, ranging from self-limiting unifocal lesions to severe, multisystem disease. As a result of new therapeutic strategies,...

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Topics

Humans
Histiocytosis, Langerhans-Cell
Histiocytes
Mutation
Disease Susceptibility

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Identifiers

PMID: 41178438
DOI: 10.3324/haematol.2024.286478
PMCID: PMC12580689

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