Article
The GTPase and Rho GAP domains of p190, a tumor suppressor protein that binds the M(r) 120,000 Ras GAP, independently function as anti-Ras tumor suppressors.
Cancer research - 15 Jun 1997
Wang D Z, Nur-E-Kamal M S, Tikoo A, Montague W, Maruta H
Abstract excerpt
p190 is a Tyr-phosphorylatable G protein of M(r) 190,000 that binds NH2-terminal SH2 domains of GAP1, a Ras GAP of M(r) 120,000. p190 contains at least two functional domains: a GTPase domain at the NH2 terminus and a GAP domain at the COOH terminus that can attenuate signal-transducing activity...
Topics
- Animals
- Cell Division
- Cell Line, Transformed
- DNA-Binding Proteins
- Fibroblasts
- GTP Phosphohydrolases
- GTPase-Activating Proteins
- Genes, Tumor Suppressor
- Genes, ras
- Guanine Nucleotide Exchange Factors
- Mice
- Mutation
- Nuclear Proteins
- Phorbol 12,13-Dibutyrate
- Phosphoproteins
- Proteins
- Proto-Oncogene Proteins c-fos
- RNA, Antisense