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Article

Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition.

Blood cancer discovery - 3 Sept 2024

Sarchi Martina, Clough Courtnee A, Crosse Edie I, Kim Jason, Baquero Galvis Laura D, Aydinyan Nelli, Wellington Rachel, Yang Feini, Gallì Anna, Creamer J Philip, Stewart Sintra, Bradley Robert K, Malcovati Luca, Doulatov Sergei

Abstract excerpt

Splicing factor SF3B1 mutations are frequent somatic lesions in myeloid neoplasms that transform hematopoietic stem cells (HSCs) by inducing mis-splicing of target genes. However, the molecular and functional consequences of SF3B1 mutations in human HSCs and progenitors (HSPCs) remain unclear. Here, we identify the mis-splicing program in human HSPCs as a targetable vulnerability by precise gene editing of SF3B1...

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Share to Checkpoint Kinase 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38856693
DOI: 10.1158/2643-3230.BCD-23-0230
PMCID: PMC11369594

Genes

SF3B1
CD34
CDC27

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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