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Article

The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway.

Cell death & disease - 5 Oct 2021

Zhao Yan, Wu Mei, Li Jing, Meng Ping, Chen Jiakui, Huang Zhibin, Xu Jin, Wen Zilong, Zhang Wenqing, Zhang Yiyue

Abstract excerpt

Hematopoietic stem cells (HSCs) possess the potential for self-renew and the capacity, throughout life, to differentiate into all blood cell lineages. Yet, the mechanistic basis for HSC development remains largely unknown. In this study, we characterized a zebrafish smu471 mutant with hematopoietic stem/progenitor cell (HSPC) defects and found that sart3 was the causative gene. RNA expression profiling of the...

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Identifiers

PMID: 34611130
DOI: 10.1038/s41419-021-04215-4
PMCID: PMC8492694

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